Episode 3.2 · 17 min

RNA Before Cells

RNA copying, chemical cycles, metabolism, and dividing compartments illuminate possible routes toward the first cells, along with the gaps experiments have yet to close.

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Visual credits

5 sources

Visual sources include third-party material incorporated into custom animations. License information is reproduced from source records; an unrecorded license does not mean a work is public domain.

  • PhilHolliger image

    X

  • Expl2282 - Flickr - NOAA Photo Library

    IFE, URI-IAO, UW, Lost City Science Party; NOAA/OAR/OER; The Lost City 2005 Expedition.

  • Chirality with hands

    Original: Unknown Vector: -- πϵρ ήλιο

  • Figure 2 from Zhu and Szostak, Coupled Growth and Division of Model Protocell Membranes: repeated micelle-fed growth into thread-like vesicles and agitation-driven division, with microscopy insets and a cycle schematic.

    Ting F. Zhu and Jack W. Szostak

    Editorial use; no open license asserted.

  • Scientific figure · source page 13

    Biorxiv

    Figure or page excerpt cropped from the source publication.

Research references

Selected sources from the episode’s research and scientific figures.

  1. 10.1126/science.adt2760 ↗
  2. 10.1038/s41557-025-01830-y ↗
  3. 10.1073/pnas.2321592121 ↗
  4. 10.1371/journal.pcbi.0010061 ↗
  5. 10.1038/ng1621 ↗
  6. 10.1073/pnas.50.5.905 ↗
  7. 10.1073/pnas.58.1.217 ↗
  8. 10.1038/s41586-022-04676-3 ↗
  9. 10.1038/s41586-025-09388-y ↗
  10. 10.1038/s41467-024-52362-x ↗
  11. 10.1039/D3CS00594A ↗
  12. 10.1038/s41467-023-36940-z ↗
  13. 10.1002/syst.202300008 ↗
  14. 10.1021/jacs.4c08226 ↗
  15. 10.1039/D2CC03541C ↗
  16. 10.1021/acs.jpcb.3c05824 ↗
  17. 10.3390/life12101595 ↗
  18. 10.1073/pnas.2423683122 ↗
  19. 10.1073/pnas.2505126122 ↗
  20. 10.1021/jacs.4c16905 ↗
  21. 10.1371/journal.pbio.3003155 ↗

Music

  • Meditation From The Star Orion
    OctahedronMusic · Envato Elements

How this film was made

Created and editorially directed by Anders Lunde using a custom production system developed over six months. AI assists research, drafting, programming, and visual production; I review and edit the material and make the final editorial decisions. Narration uses text-to-speech. Visuals combine custom-built scientific animations, AI-generated reconstructions, and credited scientific imagery.

Generated reconstructions illustrate scientific interpretations. They are distinct from photographs, specimens, and measured data.

More about the creator and production →